Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits
Identifieur interne : 000102 ( France/Analysis ); précédent : 000101; suivant : 000103Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits
Auteurs : Elisabeth Polichetti [France] ; Anne Janisson [France] ; Paulette Lechène De La Porte [France] ; Henri Portugal [France] ; Jeannie Léonardi [France] ; Antonia Luna [France] ; Philippe La Droitte [France] ; Françoise Chanussot [France]Source :
- Life Sciences [ 0024-3205 ] ; 2000.
Abstract
The aim of this work was to study the cholesterol-lowering mechanisms induced by dietary soybean lecithin in hypercholesterolemic rabbits. Male New Zealand white rabbits (n = 6 in each group) were fed for 10 weeks either a low-fat control C diet, containing 27 g fat/kg, or high-fat diets enriched with 2 g cholesterol/kg and 77 g fat/kg. The high-fat diets contained 50 g lard (L), 50 g soybean triacylglycerol (SO), or 50 g pure soybean phosphatidylcholine (PLE). PLE diet decreased by 30% β-VLDL-cholesterol, compared with SO diet. HDL2-, HDL3- and LDL-lipid contents were unchanged in the L, SO and PLE groups. In gallbladder bile, amounts of phospholipids, bile salts and cholesterol were significantly increased in PLE group by respectively 45%, 11% and 44%, in comparison with SO group. Intestinal and hepatic Hydroxy Methyl Glutaryl Coenzyme A reductase activities were not increased by PLE diet. Triacylglycerol hepatic content was lower in PLE group than in L or SO groups. Compared with triacylglycerol enriched diet, phosphatidylcholine enriched diet developed significant higher cholesterol- and triacylglycerol-lowering effects by a two-step mechanism: i) by reducing the β-VLDLs, ii) by enhancing the secretion of bile cholesterol. Such results constitute promising effects of soybean phosphatidylcholine at the hepato-biliary level, in the treatment or prevention of hyperlipidemia and related atherosclerosis.
Url:
DOI: 10.1016/S0024-3205(00)00840-7
Affiliations:
- France
- Languedoc-Roussillon-Midi-Pyrénées, Midi-Pyrénées, Provence-Alpes-Côte d'Azur
- Marseille, Revel
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Tel.: 33 4 91 75 86 00; fax: 33 4 91 75 15 62.(F. Chanussot)</wicri:noCountry></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="2563">2563</biblScope><biblScope unit="page" to="2576">2576</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">FBC86F41E53CC687CF594F799ECD02DB05066F23</idno><idno type="DOI">10.1016/S0024-3205(00)00840-7</idno><idno type="PII">S0024-3205(00)00840-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to study the cholesterol-lowering mechanisms induced by dietary soybean lecithin in hypercholesterolemic rabbits. Male New Zealand white rabbits (n = 6 in each group) were fed for 10 weeks either a low-fat control C diet, containing 27 g fat/kg, or high-fat diets enriched with 2 g cholesterol/kg and 77 g fat/kg. The high-fat diets contained 50 g lard (L), 50 g soybean triacylglycerol (SO), or 50 g pure soybean phosphatidylcholine (PLE). PLE diet decreased by 30% β-VLDL-cholesterol, compared with SO diet. HDL2-, HDL3- and LDL-lipid contents were unchanged in the L, SO and PLE groups. In gallbladder bile, amounts of phospholipids, bile salts and cholesterol were significantly increased in PLE group by respectively 45%, 11% and 44%, in comparison with SO group. Intestinal and hepatic Hydroxy Methyl Glutaryl Coenzyme A reductase activities were not increased by PLE diet. Triacylglycerol hepatic content was lower in PLE group than in L or SO groups. Compared with triacylglycerol enriched diet, phosphatidylcholine enriched diet developed significant higher cholesterol- and triacylglycerol-lowering effects by a two-step mechanism: i) by reducing the β-VLDLs, ii) by enhancing the secretion of bile cholesterol. Such results constitute promising effects of soybean phosphatidylcholine at the hepato-biliary level, in the treatment or prevention of hyperlipidemia and related atherosclerosis.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon-Midi-Pyrénées</li><li>Midi-Pyrénées</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li><li>Revel</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Polichetti, Elisabeth" sort="Polichetti, Elisabeth" uniqKey="Polichetti E" first="Elisabeth" last="Polichetti">Elisabeth Polichetti</name></region><name sortKey="Chanussot, Francoise" sort="Chanussot, Francoise" uniqKey="Chanussot F" first="Françoise" last="Chanussot">Françoise Chanussot</name><name sortKey="Chanussot, Francoise" sort="Chanussot, Francoise" uniqKey="Chanussot F" first="Françoise" last="Chanussot">Françoise Chanussot</name><name sortKey="De La Porte, Paulette Lechene" sort="De La Porte, Paulette Lechene" uniqKey="De La Porte P" first="Paulette Lechène" last="De La Porte">Paulette Lechène De La Porte</name><name sortKey="Janisson, Anne" sort="Janisson, Anne" uniqKey="Janisson A" first="Anne" last="Janisson">Anne Janisson</name><name sortKey="La Droitte, Philippe" sort="La Droitte, Philippe" uniqKey="La Droitte P" first="Philippe" last="La Droitte">Philippe La Droitte</name><name sortKey="Leonardi, Jeannie" sort="Leonardi, Jeannie" uniqKey="Leonardi J" first="Jeannie" last="Léonardi">Jeannie Léonardi</name><name sortKey="Luna, Antonia" sort="Luna, Antonia" uniqKey="Luna A" first="Antonia" last="Luna">Antonia Luna</name><name sortKey="Portugal, Henri" sort="Portugal, Henri" uniqKey="Portugal H" first="Henri" last="Portugal">Henri Portugal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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